c-Jun is required for the specification of joint cell fates
نویسندگان
چکیده
منابع مشابه
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.
Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun N-terminal kinase (JNK) is highly activated in RA fibroblast-like synoviocytes and synovium. However, defining the precise function of this kinase has been difficult because a selective JNK inhibitor has not been available. We now report the use...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2013
ISSN: 0890-9369
DOI: 10.1101/gad.209239.112